Bill Anoatubby began work for the Chickasaw Nation in 1975 as its health services director. ​​A year later, he was asked to direct its finance department. In October 1978, he was promoted to the position of special assistant to the governor and controller. In 1979, he was elected as the tribe’s first Lt. Governor. Governor Anoatubby was elected to his first term as Governor in 1987. In his first term, Governor Anoatubby established goals of economic development and self-sufficiency for the Chickasaw Nation and its people.

Today, the Chickasaw Nation is well on the way to achieving those goals. In 1987, the tribe had about 250 employees. Today, the Chickasaw Nation employs nearly 13,000 people. The financial condition of the tribe has been improved tremendously. Funding for tribal operations has grown exponentially. Tribal assets have grown twenty-fold. Governor Anoatubby is committed to meeting the needs of Chickasaw people through programs and services.

Governor Anoatubby and his wife, Janice, have two sons, Brian and Chris and five grandchildren, Brendan, Eryn, Chloe, Sydney and Preslea.